Aspirin has caused problems! People who take it regularly must pay attention to 5 things!

1、 Pay attention to the dosage

Currently, aspirin is used in cardiovascular and cerebrovascular diseases, with a daily dosage of75-150milligrams. A dosage that is too small cannot effectively prevent bleeding, while a dosage that is too large increases the risk of bleeding without increasing the therapeutic effect.^[7].

In the application of cancer prevention and metastasis prevention, there is currently no clear clinical guideline for the optimal dosage.

2.Pay attention to bleeding reactions

The mechanism of action of aspirin may lead to abnormalities in the coagulation mechanism, increase the risk of bleeding, and cause gastrointestinal bleeding, hematoma, gingival bleeding, nosebleeds, subcutaneous bleeding, urogenital bleeding, etc. During the use of aspirin, be sure to pay attention to these abnormal bleeding situations and consult a doctor in a timely manner.

3、 Pay attention to gastrointestinal issues

Due to the salicylic acid structure in aspirin, frequent use can damage the lining of the gastrointestinal tract, increasing the risk of duodenal ulcers, Crohn's disease, inflammatory bowel disease(IBD) and intestinal perforation. If aspirin users experience symptoms such as nausea, vomiting, upper abdominal pain, vomiting blood, black stool, anemia, dizziness, etc., they should consider gastrointestinal problems caused by the medication.

4、 Pay attention to medication time

Aspirin is divided into two categories: regular preparations and enteric coated tablets. Regular preparations are recommended to be taken after meals to reduce direct damage to the gastric mucosa, while enteric coated aspirin tablets are more effective when taken 15 to 30 minutes before meals.

5. Pay attention to allergic reactions

Some people may be allergic to aspirin, with common allergic reactions such as sneezing, skin redness and itching, and asthma.

Special reminder

Aspirin must be taken according to doctor's advice, and attention should be paid to medication safety.

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Reference source:

[1] https://doi.org/10.1016/S0140-6736(20)30366-4

[2] Elwood, P., Morgan, G., Watkins, J. et al. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. Br J Cancer (2023). doi: 10.1038/s41416-023-02506-5

[3] Teng-Yu Lee et al, Daily aspirin associated with a reduced risk of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease: a population-based cohort study. eClinicalMedicine. DOI: 10.1016/j.eclinm.2023.102065

[4] Christina A. Clarke, Alison J. Canchola, Lisa M. Moy, et al. Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study. Breast Cancer Research. 1 May 2017, DOI: 10.1186/s13058-017-0840-7.

[5] Melissa A Merritt et al: "Pre-diagnosis and post-diagnosis use of common analgesics and ovarian cancer prognosis (NHS/NHSII): a cohort study". The Lancet Oncology, July 17, 2018

[6] Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity. Nature (2025). DOI: https://doi.org/10.1038/s41586-025-08626-7

[7] Li Xiaoli, Wang Yongji, Fan Li, et al Analysis of the correlation between aspirin dosage and antiplatelet effect of aspirin in elderly population using propensity score matching method [J]. Chinese Journal of Geriatric Cardiology and Cerebrovascular Diseases, 2015, 000(009):925-928.

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Professor Zhang Minghui, a Ph.D. in immunology from Tsinghua University School of Medicine, has led a research team for over 20 years since the discovery of vNKT cells in 2002. They have accumulated experience in treating over 700 cases of solid tumors, covering almost all common solid tumors. The research results fully demonstrate the great value of vNKT cells in the treatment of solid tumors.

It is suitable for postoperative patients with high pathological malignancy or a risk of recurrence; patients whose tumors have been basically controlled but not cured through conventional treatments such as chemotherapy, radiotherapy, and targeted therapy; patients with persistent high carcinogenic factors; and patients intolerant to radiotherapy and chemotherapy. If these patients do not receive effective follow-up treatment after traditional anti-tumor therapy, recurrence, metastasis, or reoccurrence of tumors will be highly probable. In this case, vNKT cell therapy is an ideal follow-up treatment method that can significantly improve patient prognosis.

Written by Zhang Tuo  

Reviewed by: Qiao Jiacheng, Wang Ying, Gao Chen

Edited/typeset by: Zhang Jiao

 

 

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